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 | Acceso al texto completo restringido a Biblioteca INIA La Estanzuela. Por información adicional contacte bib_le@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha actual : |
13/09/2017 |
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Actualizado : |
18/09/2017 |
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Tipo de producción científica : |
Abstracts/Resúmenes |
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Autor : |
BERTON, MP.; DE OLIVEIRA SILVA, R.M.; PERIPOLLI, E.; STAFUZZA, N.B.; FERNÁNDEZ, J.; SAURA, S.; VILLANUEVA, B.; TORO, M.A.; BANCHERO, G.; OLIVEIRA, P.S.; ELER, J.P.; BALDI, F.; FERRAZ, J.B.S. |
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Afiliación : |
Department of Animal Science, School of Agricultural and Veterinarian Sciences, Sao Paulo State University, Jaboticabal, Brazil.; Department of Animal Science, School of Agricultural and Veterinarian Sciences, Sao Paulo State University, Jaboticabal, Brazil.; Department of Animal Science, School of Agricultural and Veterinarian Sciences, Sao Paulo State University, Jaboticabal, Brazil.; Departamento de Ciências Exatas, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil.; Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, España.; Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, España.; Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, España.; Animal Production Department, Universidad Politécnica de Madrid, Madrid, España.; GEORGGET ELIZABETH BANCHERO HUNZIKER, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; University of Sao Paulo, Pirassununga, Brazil.; NAP-GMABT/ FZEA/University of Sao Paulo, Pirassununga, Brazil.; FERNANDO BALDI, Department of Animal Science, School of Agricultural and Veterinarian Sciences, Sao Paulo State University, Jaboticabal, Brazil.; NAP-GMABT/ FZEA/University of Sao Paulo, Pirassununga, Brazil. |
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Título : |
Genomic regions and pathways associated with resistance to gastrointestinal parasites in tropical sheep breed. |
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Fecha de publicación : |
2017 |
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Fuente / Imprenta : |
Journal of Animal Science, 2017, v.95, suppl.4.p.107. |
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DOI : |
10.2527/asasann.2017.216 |
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Idioma : |
Inglés |
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Contenido : |
Abstract.
The aim of this study was to estimate variance components and to identify genomic regions and pathways associated with
resistance to gastrointestinal parasites, particularly Haemonchus contortus, in Santa Inês sheep, a Brazilian breed adapted
to tropical climate. The degree of anemia assessed by the FAMACHA card (FAM) and the egg counts per gram of feces
(EPG) were evaluated to verify the resistance to gastrointestinal parasites. A total of 576 animals were genotyped using
12,785 SNPs of the Ovine SNP12k BeadChip (Illumina, Inc.). The variance components were estimated using a single trait
model by single step genomic BLUP (ssGBLUP) procedure.The overall LD mean between marker pairs measured by r2
was 0.23. Heritability estimates were low for EPG (0.11) and high for FAM (0.35). A total of 22 and 21 important windows
for EPG and FAM traits were identified. The results of the enriched genes and functional grouping analyses showed that
genes associated with FAM and OPG are involved in functions related to the body?s immune and defense response. The
CCL28 gene located in OAR16 identified both for EPG and FAM acts as a chemotactic for CD4 and CD8 inactive T cells.
The metabolic pathway involved in the CCL28 gene and in other genes associated with EPG and FAM, which are related
to immunoglobulin synthesis in the intestine. The high heritability observed for FAM suggests that good genetic progress
should be possible in selective breeding programs for Santa Inês sheep besides the fact that the FAM is the most
precise method to identify an infection by Haemonchus when compared to EPG. This study reported for the first time estimates
of linkage disequilibrium between markers and genetic parameters for traits related to gastrointestinal parasite resistance
in the Santa Inês sheep breed. MenosAbstract.
The aim of this study was to estimate variance components and to identify genomic regions and pathways associated with
resistance to gastrointestinal parasites, particularly Haemonchus contortus, in Santa Inês sheep, a Brazilian breed adapted
to tropical climate. The degree of anemia assessed by the FAMACHA card (FAM) and the egg counts per gram of feces
(EPG) were evaluated to verify the resistance to gastrointestinal parasites. A total of 576 animals were genotyped using
12,785 SNPs of the Ovine SNP12k BeadChip (Illumina, Inc.). The variance components were estimated using a single trait
model by single step genomic BLUP (ssGBLUP) procedure.The overall LD mean between marker pairs measured by r2
was 0.23. Heritability estimates were low for EPG (0.11) and high for FAM (0.35). A total of 22 and 21 important windows
for EPG and FAM traits were identified. The results of the enriched genes and functional grouping analyses showed that
genes associated with FAM and OPG are involved in functions related to the body?s immune and defense response. The
CCL28 gene located in OAR16 identified both for EPG and FAM acts as a chemotactic for CD4 and CD8 inactive T cells.
The metabolic pathway involved in the CCL28 gene and in other genes associated with EPG and FAM, which are related
to immunoglobulin synthesis in the intestine. The high heritability observed for FAM suggests that good genetic progress
should be possible in selective breeding programs for Santa Inês sheep bes... Presentar Todo |
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Palabras claves : |
GWAS; LINKAGE DISEQUILIBRIUM; RAZAS DE OVEJAS TROPICALES; RESISTENCIA A PARÁSITOS GASTROINTESTINALES. |
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Asunto categoría : |
E16 Enfermedades de los animales |
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Marc : |
LEADER 02797naa a2200325 a 4500
001 1057562
005 2017-09-18
008 2017 bl uuuu u00u1 u #d
024 7 $a10.2527/asasann.2017.216$2DOI
100 1 $aBERTON, MP.
245 $aGenomic regions and pathways associated with resistance to gastrointestinal parasites in tropical sheep breed.$h[electronic resource]
260 $c2017
520 $aAbstract. The aim of this study was to estimate variance components and to identify genomic regions and pathways associated with resistance to gastrointestinal parasites, particularly Haemonchus contortus, in Santa Inês sheep, a Brazilian breed adapted to tropical climate. The degree of anemia assessed by the FAMACHA card (FAM) and the egg counts per gram of feces (EPG) were evaluated to verify the resistance to gastrointestinal parasites. A total of 576 animals were genotyped using 12,785 SNPs of the Ovine SNP12k BeadChip (Illumina, Inc.). The variance components were estimated using a single trait model by single step genomic BLUP (ssGBLUP) procedure.The overall LD mean between marker pairs measured by r2 was 0.23. Heritability estimates were low for EPG (0.11) and high for FAM (0.35). A total of 22 and 21 important windows for EPG and FAM traits were identified. The results of the enriched genes and functional grouping analyses showed that genes associated with FAM and OPG are involved in functions related to the body?s immune and defense response. The CCL28 gene located in OAR16 identified both for EPG and FAM acts as a chemotactic for CD4 and CD8 inactive T cells. The metabolic pathway involved in the CCL28 gene and in other genes associated with EPG and FAM, which are related to immunoglobulin synthesis in the intestine. The high heritability observed for FAM suggests that good genetic progress should be possible in selective breeding programs for Santa Inês sheep besides the fact that the FAM is the most precise method to identify an infection by Haemonchus when compared to EPG. This study reported for the first time estimates of linkage disequilibrium between markers and genetic parameters for traits related to gastrointestinal parasite resistance in the Santa Inês sheep breed.
653 $aGWAS
653 $aLINKAGE DISEQUILIBRIUM
653 $aRAZAS DE OVEJAS TROPICALES
653 $aRESISTENCIA A PARÁSITOS GASTROINTESTINALES
700 1 $aDE OLIVEIRA SILVA, R.M.
700 1 $aPERIPOLLI, E.
700 1 $aSTAFUZZA, N.B.
700 1 $aFERNÁNDEZ, J.
700 1 $aSAURA, S.
700 1 $aVILLANUEVA, B.
700 1 $aTORO, M.A.
700 1 $aBANCHERO, G.
700 1 $aOLIVEIRA, P.S.
700 1 $aELER, J.P.
700 1 $aBALDI, F.
700 1 $aFERRAZ, J.B.S.
773 $tJournal of Animal Science, 2017$gv.95, suppl.4.p.107.
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